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Abstract Background To investigate the impact of wearing spectacle lenses with highly aspherical lenslets (HAL) for 3 years and the impact of switching from single-vision lenses (SVL) to HAL on choroidal thickness (ChT). Methods Fifty-one participants who had already worn HAL for 2 years continued wearing them for an additional year (HAL group). Further, 50 and 41 participants who had worn spectacle lenses with slightly aspherical lenslets (SAL) and SVL for 2 years, respectively, switched to wearing HAL for another year (SAL-HAL and SVL-HAL groups). Additionally, 48 new participants aged 10–15 years were enrolled to wear SVL at the third year (new-SVL group). ChT was measured every 6 months throughout the study. Results Significant differences were observed in the changes in ChT among the four groups at the third year (all P 0.05). When comparing the changes in ChT for 3 years among the HAL, SAL-HAL, and SVL-HAL groups, significant differences were found before switching to HAL, but these differences were abolished after all participants switched to HAL. Conclusions Compared to those in the SVL group, choroid thinning was significantly inhibited in all the HAL groups. Wearing HAL for 3 years no longer had a choroidal thickening effect but could still inhibit choroidal thinning compared to wearing SVL. Trial registration The study was registered at the Chinese Clinical Trial Registry (ChiCTR1800017683), http://www.chictr.org.cn/showproj.aspx?proj=29789 .

Abstract Background n-of-1 trials are a type of crossover trial designed to optimise the evaluation of health technologies in individual patients. This trial design may be considered for the evaluation of health technologies in rare conditions where fewer patients are available to take part in research. This review describes the characteristics of randomised n-of-1 trials conducted over the span of 12 years, including how the n-of-1 design has been employed to study both rare and non-rare conditions. Methods Databases and clinical trials registries were searched for articles including “n-of-1” in the title between 2011 and 2023. The reference lists of reviews identified by the searches were searched for any additional eligible articles. Randomised n-of-1 trials were selected for inclusion and data were extracted on a range of design, population, and analysis characteristics. Descriptive statistics were produced for all variables. Results We identified 74 studies meeting our eligibility criteria, 13 of which (17.6%) were conducted in rare conditions. They were conducted in a range of clinical areas with the most common being neurological conditions (n = 16, 21.6%). The median (Q1, Q3) number of participants randomised was 9 (4, 20) and 12 trials (16.2%) involved a single patient only. Forty-six (62.2%) trials evaluated pharmaceutical interventions and 49 (66.2%) trials were placebo controlled. Trials had a median (Q1, Q3) of six (4, 8) periods and 61 (82.4%) compared two health technologies. Fifty-seven (77.0%) trials incorporated blinding and 32 (43.2%) had a washout period. Forty-nine trials (66.2%) used patient-reported outcome measures (PROMs) to assess the primary outcome. Trials used a range of approaches to analysis and 48 (64.9%) combined data from multiple patients. The characteristics of the n-of-1 trials conducted in rare conditions were generally consistent with those in non-rare conditions. Conclusions n-of-1 trials are still underused and the application of the n-of-1 design for the evaluation of health technologies for rare diseases has been particularly limited. We have summarised the characteristics of randomised n-of-1 trials in rare and non-rare conditions. We hope that it can inform researchers in the design of future n-of-1 studies. Further work is required to provide guidance on specific design considerations, implementation, and statistical analysis of these studies. Trial registration Not applicable.

The distributed flowshop has been a hot topic in research in recent years. This paper considers a distributed permutation flowshop scheduling problem with an assemble machine, so-called the distributed assembly permutation flowshop scheduling problem (DAPFSP), with total tardiness criterion. We propose an effective memetic algorithm (EMA). Firstly, a constructive heuristic combining the well-known earliest due date rule and largest processing time rule is presented for producing a seed sequence. On this basis, an effective initialisation method is used to generate an initial population with a high level of quality and diversity. The EMA uses a new structure of a small iteration nested within a large iteration. Moreover, an improved crossover and mutation expand the solution space in a good direction. According to different operation situations and objects, we design four targeted and flexible local search methods. We evaluate the strategies of the EMA, compare and analyse it with seven efficient algorithms based on the 810 benchmark instances. The experimental results confirm the effectiveness and efficiency of the proposed EMA. [ABSTRACT FROM AUTHOR]

Recently, there has been a rapid increase in the volume of medical image repositories because of the maximized utilization of digitized image data in hospitals. As a result, there is a complexity in querying and handling such large databases, which has led to the development of a novel Content-Based Medical Image Retrieval (CBMIR) technique. In this work, the CBMIR technique is developed using three types of visual features (i.e., color, texture and shape) along with 12 distance measures, and is optimized with the Crossover-Gravitational Search Algorithm (CRO-GSA). For ease, we named this technique Content-Based Medical Image Retrieval using Visual features with CRO-GSA (CBMIRVC). The initial step of our CBMIRVC technique is to extract three types of visual features from the images. Then, each type of feature is employed with a suitable distance measure, which is used for the computation of image similarities between the medical images in the database and a provided query image. The optimization of our proposed CBMIRVC technique is done by the CRO-GSA algorithm. This algorithm optimizes the CBMIRVC technique by identifying the optimal combinations of visual features and similarity measures. Additionally, optimal weights are computed in accordance with the three types of features for the three similarities. Experimental validations were done using retrieved cancer-related and endoscopic color images from databases holding numerous image categories. The experimental outcome shows that our proposed CBMIRVC technique outperforms other conventional image retrieval techniques by effectively retrieving similar images from large databases. [ABSTRACT FROM AUTHOR]

SUMMARY: Thermosensitive genic female sterility (TGFS) is a promising property to be utilized for hybrid breeding. Here, we identified a rice TGFS line, tfs2, through an ethyl methyl sulfone (EMS) mutagenesis strategy. This line showed sterility under high temperature and became fertile under low temperature. Few seeds were produced when the tfs2 stigma was pollinated, indicating that tfs2 is female sterile. Gene cloning and genetic complementation showed that a point mutation from leucine to phenylalanine in HEI10 (HEI10tfs2), a crossover formation protein, caused the TGFS trait of tfs2. Under high temperature, abnormal univalents were formed, and the chromosomes were unequally segregated during meiosis, similar to the reported meiotic defects in oshei10. Under low temperature, the number of univalents was largely reduced, and the chromosomes segregated equally, suggesting that crossover formation was restored in tfs2. Yeast two‐hybrid assays showed that HEI10 interacted with two putative protein degradation‐related proteins, RPT4 and SRFP1. Through transient expression in tobacco leaves, HEI10 were found to spontaneously aggregate into dot‐like foci in the nucleus under high temperature, but HEI10tfs2 failed to aggregate. In contrast, low temperature promoted HEI10tfs2 aggregation. This result suggests that protein aggregation at the crossover position contributes to the fertility restoration of tfs2 under low temperature. In addition, RPT4 and SRFP1 also aggregated into dot‐like foci, and these aggregations depend on the presence of HEI10. These findings reveal a novel mechanism of fertility restoration and facilitate further understanding of HEI10 in meiotic crossover formation. Significance Statement: Our study promotes the understanding of HEI10/TFS2 for meiotic crossover formation and provides a mechanism for the female fertility restoration of TGFS lines under low temperature. [ABSTRACT FROM AUTHOR]

Background: n-of-1 trials are a type of crossover trial designed to optimise the evaluation of health technologies in individual patients. This trial design may be considered for the evaluation of health technologies in rare conditions where fewer patients are available to take part in research. This review describes the characteristics of randomised n-of-1 trials conducted over the span of 12 years, including how the n-of-1 design has been employed to study both rare and non-rare conditions. Methods: Databases and clinical trials registries were searched for articles including "n-of-1" in the title between 2011 and 2023. The reference lists of reviews identified by the searches were searched for any additional eligible articles. Randomised n-of-1 trials were selected for inclusion and data were extracted on a range of design, population, and analysis characteristics. Descriptive statistics were produced for all variables. Results: We identified 74 studies meeting our eligibility criteria, 13 of which (17.6%) were conducted in rare conditions. They were conducted in a range of clinical areas with the most common being neurological conditions (n = 16, 21.6%). The median (Q1, Q3) number of participants randomised was 9 (4, 20) and 12 trials (16.2%) involved a single patient only. Forty-six (62.2%) trials evaluated pharmaceutical interventions and 49 (66.2%) trials were placebo controlled. Trials had a median (Q1, Q3) of six (4, 8) periods and 61 (82.4%) compared two health technologies. Fifty-seven (77.0%) trials incorporated blinding and 32 (43.2%) had a washout period. Forty-nine trials (66.2%) used patient-reported outcome measures (PROMs) to assess the primary outcome. Trials used a range of approaches to analysis and 48 (64.9%) combined data from multiple patients. The characteristics of the n-of-1 trials conducted in rare conditions were generally consistent with those in non-rare conditions. Conclusions: n-of-1 trials are still underused and the application of the n-of-1 design for the evaluation of health technologies for rare diseases has been particularly limited. We have summarised the characteristics of randomised n-of-1 trials in rare and non-rare conditions. We hope that it can inform researchers in the design of future n-of-1 studies. Further work is required to provide guidance on specific design considerations, implementation, and statistical analysis of these studies. Trial registration: Not applicable. [ABSTRACT FROM AUTHOR]

In their lead article, Klug et al. conceptualize job insecurity as a multilevel construct whereby individuals are situated in mesolevel and macrolevel contexts. In our article, we advocate deepening the current conceptual model with two partially intertwined perspectives. First, we suggest adding a systemic perspective at the mesolevel that considers individuals' nestedness in family and relationship systems, thus looking into how individuals' job insecurity affects close others (i.e., [romantic] partners and family members) and how close others affect individuals' experience of and reactions to job insecurity. To illustrate our propositions, we draw on the crossover model and the systemic‐transactional model of stress processes within romantic couples. Second, we suggest adding a lifespan perspective that considers biographic time as a facet of the individual level in addition to historical time on the macrolevel. In doing so, we draw on the notion of path dependence and processes related to social learning. We advocate for future research taking into account the various, intertwined levels on which job insecurity operates to fully understand job insecurity as well as its consequences and remedies. [ABSTRACT FROM AUTHOR]

Through job crafting, employees proactively change or modify their tasks, thus reducing adverse job demands or protecting resources. There is still a lack of understanding of the impact that job crafting may have on colleagues at work (crossover effect), and how this may affect their ability to disconnect from work (spillover effect). In the present daily diary study, we examine these two processes among 82 dyads of colleagues (N = 164 employees) over five consecutive working days (N = 820 observations). We found a number of crossover and differential spillover effects. For example, when the focal employee starts new challenging projects, their colleague reacts by reducing the number of stressful tasks. This, in turn, affects psychological detachment from work. Specifically, whereas increasing challenging demands hinders daily detachment, decreasing hindering demands facilitates it. Taken together, these findings demonstrate that the impact of job crafting goes beyond the focal employee and beyond the work domain. [ABSTRACT FROM AUTHOR]

Sleep disturbance is a major issue for patients with chronic pain. Melatonin has been shown to improve symptoms of fibromyalgia, but its efficacy in other chronic non-malignant pain conditions is not fully known. Hence, we determined the effect of melatonin in patients with severe noncancer chronic pain. This was a randomised double-blinded crossover trial of modified-release melatonin as Circadin™ compared with placebo. Sixty male and female subjects with chronic severe pain were randomised to receive either 2 mg of Circadin™ or placebo before sleep for 6 weeks, followed by a >4 week washout, then crossing over to the other treatment. Sleep disturbance, quality, and latency were measured using three different validated sleep assessment tools. The primary outcome measure was self-reported sleep disturbance after 6 weeks of treatment. Adverse events were also recorded. Sleep disturbance after 6 weeks was not significantly altered by melatonin treatment, but differences between melatonin and placebo treatment periods after 3 weeks were seen: sleep disturbance (P =0.014), latency (P =0.04), overall sleep quality (P =0.004), and effect of pain on sleep (P =0.032). Pain intensity scores improved during both treatment periods (both P <0.001). There were no differences in adverse events between treatment periods. Circadin™ treatment did not improve sleep disturbance in patients with severe chronic pain compared with placebo at 6 weeks, but there were consistent improvements in aspects of sleep in the shorter term. Given its favourable safety profile, it could be beneficial for some patients with chronic pain. ISRCTN12861060. [ABSTRACT FROM AUTHOR]

Dynamic linear functions on the boolean hypercube are functions which assign to each bit a positive weight, but the weights change over time. Throughout optimization, these functions maintain the same global optimum, and never have defecting local optima. Nevertheless, it was recently shown [Lengler, Schaller, FOCI 2019] that the (1 + 1) -Evolutionary Algorithm needs exponential time to find or approximate the optimum for some algorithm configurations. In this experimental paper, we study the effect of larger population sizes for dynamic binval, the extreme form of dynamic linear functions. We find that moderately increased population sizes extend the range of efficient algorithm configurations, and that crossover boosts this positive effect substantially. Remarkably, similar to the static setting of monotone functions in [Lengler, Zou, FOGA 2019], the hardest region of optimization for (μ + 1) -EA is not close the optimum, but far away from it. In contrast, for the (μ + 1) -GA, the region around the optimum is the hardest region in all studied cases.Kindly check and confirm the inserted city name is correctly identified.Correct. [ABSTRACT FROM AUTHOR]

Accurate segregation of homologous chromosomes during meiosis depends on both the presence and the regulated placement of crossovers (COs). The centromere effect, or CO exclusion in pericentromeric regions of the chromosome, is a meiotic CO patterning phenomenon that helps prevent nondisjunction, thereby protecting against chromosomal disorders and other meiotic defects. Despite being identified nearly a century ago, the mechanisms behind this fundamental cellular process remain unknown, with most studies of the Drosophila centromere effect focusing on local influences of the centromere and pericentric heterochromatin. In this study, we sought to investigate whether dosage changes in centromere number and repetitive DNA content affect the strength of the centromere effect, using phenotypic recombination mapping. Additionally, we studied the effects of repetitive DNA function on centromere effect strength using satellite DNA–binding protein mutants displaying defective centromere-clustering in meiotic nuclei. Despite what previous studies suggest, our results show that the Drosophila centromere effect is robust to changes in centromere number, repetitive DNA content, as well as repetitive DNA function. Our study suggests that the centromere effect is unlikely to be spatially controlled, providing novel insight into the mechanisms behind the Drosophila centromere effect. [ABSTRACT FROM AUTHOR]

Although ADAURA (ClinicalTrials.gov identifier NCT02511106) was a positive trial that produced a significant improvement in both disease‐free survival and overall survival, the limited crossover to postprotocol osimertinib and some other methodological issues detract from the cancer community's ability to distinguish the benefits of timing of osimertinib versus overall access to osimertinib at a later point. Discrete refinements can be applied to global, randomized phase 3 trials to ensure their design optimally addresses the key clinical question while reducing disparities in best management practices based on resources across health care systems. [ABSTRACT FROM AUTHOR]

Summary: Combining two or more related homoeologous genomes in a single nucleus, newly formed allopolyploids must rapidly adapt meiosis to restore balanced chromosome segregation, production of euploid gametes and fertility. The poor fertility of such neo‐allopolyploids thus strongly selects for the limitation or avoidance of genetic crossover formation between homoeologous chromosomes.In this study, we have reproduced the interspecific hybridization between Arabidopsis thaliana and Arabidopsis arenosa leading to the allotetraploid Arabidopsis suecica and have characterized the first allopolyploid meioses.First‐generation neo‐allopolyploid siblings vary considerably in fertility, meiotic behavior and levels of homoeologous recombination. We show that centromere dynamics at early meiosis is altered in synthetic neo‐allopolyploids compared with evolved A. suecica, with a significant increase in homoeologous centromere interactions at zygotene. At metaphase I, the presence of multivalents involving homoeologous chromosomes confirms that homoeologous recombination occurs in the first‐generation synthetic allopolyploid plants and this is associated with a significant reduction in homologous recombination, compared to evolved A. suecica.Together, these data strongly suggest that the fidelity of recombination partner choice, likely during the DNA invasion step, is strongly impaired during the first meiosis of neo‐allopolyploids and requires subsequent adaptation. [ABSTRACT FROM AUTHOR]

A new swarm-based metaheuristic that is also enriched with the crossover technique called swarm flip-crossover algorithm (SFCA) is introduced in this work. SFCA uses swarm intelligence as its primary technique and the crossover as its secondary one. It consists of three searches in every iteration. The swarm member walks toward the best member as the first search. The central point of the swarm becomes the target in the second search. There are two walks in the second search. The first walk is getting closer to the target, while the second is avoiding the target. The better result between these two walks becomes the candidate for the replacement. In the third search, the swarm member performs balance arithmetic crossover with the central point of the space or jumps to the opposite location within the area (flipping). The assessment is taken by confronting SFCA with five new metaheuristics: slime mold algorithm (SMA), golden search optimization (GSO), osprey optimization algorithm (OOA), coati optimization algorithm (COA), and walrus optimization algorithm (WaOA) in handling the set of 23 functions. The result shows that SFCA performs consecutively better than SMA, GSO, OOA, COA, and WaOA in 20, 23, 17, 17, and 17 functions. [ABSTRACT FROM AUTHOR]

Purpose: There is a growing interest in performing coronary artery and neurovascular interventions via the radial artery; however, few studies have examined the outcomes of transradial carotid stenting. Therefore, our study aimed to compare cerebrovascular outcomes and crossover rates in carotid stenting between transradial and traditional transfemoral approaches. Methods: A systematic review was performed by searching three electronic databases from inception to June 2022 in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. In addition, random effect meta-analysis was used to pool the odds ratios (ORs) for stroke, transient ischemic attack, major adverse cardiac events, death, major vascular access site complications, and procedure crossover rates between the transradial and transfemoral approaches. Results: A total of 6 studies were included involving a total of n = 567 transradial and n = 6176 transfemoral procedures. The ORs for stroke, transient ischemic attack, and major adverse cardiac events were 1.43 (95% confidence interval, CI 0.72–2.86, I2 = 0), 0.51 (95% CI 0.17–1.54, I2 = 0), and 1.08 (95% CI 0.62–1.86, I2 = 0), respectively. Neither the major vascular access site complication rate (OR 1.11, 95% CI 0.32–3.87, I2 = 0) nor crossover rate (OR 3.94, 95% CI 0.62–25.11, I2 = 57%) showed statistically significant differences between the two approaches. Conclusion: The modest quality of the data suggested comparable procedural outcomes between the transradial and transfemoral approaches when performing carotid stenting; however, high level evidence regarding postoperative brain images and risk of stroke in transradial carotid stenting are lacking. Therefore, it is reasonable for interventionists to weigh up the risks of neurological events and potential benefits, including fewer access site complications, before choosing the radial or femoral arteries as access sites. Future large-scale randomized controlled trials are imperative. [ABSTRACT FROM AUTHOR]

Abstract Background Centromeres load kinetochore complexes onto chromosomes, which mediate spindle attachment and allow segregation during cell division. Although centromeres perform a conserved cellular function, their underlying DNA sequences are highly divergent within and between species. Despite variability in DNA sequence, centromeres are also universally suppressed for meiotic crossover recombination, across eukaryotes. However, the genetic and epigenetic factors responsible for suppression of centromeric crossovers remain to be completely defined. Results To explore the centromere-proximal meiotic recombination landscape, we map 14,397 crossovers against fully assembled Arabidopsis thaliana (A. thaliana) genomes. A. thaliana centromeres comprise megabase satellite repeat arrays that load nucleosomes containing the CENH3 histone variant. Each chromosome contains a structurally polymorphic region of ~3–4 megabases, which lack crossovers and include the satellite arrays. This polymorphic region is flanked by ~1–2 megabase low-recombination zones. These recombination-suppressed regions are enriched for Gypsy/Ty3 retrotransposons, and additionally contain expressed genes with high genetic diversity that initiate meiotic recombination, yet do not crossover. We map crossovers at high-resolution in proximity to CEN3, which resolves punctate centromere-proximal hotspots that overlap gene islands embedded in heterochromatin. Centromeres are densely DNA methylated and the recombination landscape is remodelled in DNA methylation mutants. We observe that the centromeric low-recombining zones decrease and increase crossovers in CG (met1) and non-CG (cmt3) mutants, respectively, whereas the core non-recombining zones remain suppressed. Conclusion Our work relates the genetic and epigenetic organization of A. thaliana centromeres and flanking pericentromeric heterochromatin to the zones of crossover suppression that surround the CENH3-occupied satellite repeat arrays.

This paper introduces an innovative $4 \times 4$ dual-band Butler matrix (BM) characterized by compactness and an enhanced frequency ratio (K). The design employs meandered lines and an interdigital capacitor (IDC) unit-cell-based composite right/left-handed transmission-line (CRLH-TL) metamaterial (MTM) structure. The BM integrates compact dual-band 3 dB branch-line couplers (BLC), a 0 dB crossover, and dual-band ±45° phase shifters on a single Rogers RT5880 substrate having relative permittivity $\varepsilon _{r}$ of 2.2 and thickness $h$ of 0.787 mm. Simulations and measurement results demonstrate reflection and isolation coefficients exceeding −20 dB at all ports, with obtained insertion loss of −6±3 dB over the 0.7 GHz and 3.5 GHz frequency bands. The achieved output phase differences of ±45°, ±135°, ±135°, and ±45° at the designed frequencies indicate a maximum average phase tolerance of ±4.5° concerning the ideal values. Importantly, the BM’s overall dimensions are 143 mm $ \times 186$ mm, resulting in an impressive 78% size reduction compared to traditional T-shaped BM designs. The proposed configuration is designed and simulated using CST Microwave Studio, with the agreement between simulated and measured parameters highlighting design reliability and effectiveness. Additionally, a performance evaluation comparing the proposed BM with existing circuits reveals its suitability for sub-6 GHz 5G dual-band antenna array beamforming networks (BFN) due to its compact size and improved band ratio.

Current wireless communications urgently need to provide huge data rates, high gain and high directivity radiation pattern beams. Therefore, beamforming networks (BFNs) are introduced to provide these needs. Butler matrix (BM) is a type of beamforming network, which can be realized using fixed network circuits and feeds the antenna array. BM at high frequency suffers from components loss and phase error for massive network, especially when it is implemented using common microstrip structures. Different transmission lines such as waveguide and substrate integrated waveguide (SIW) are studied and introduced to realize Butler matrix. SIW structures are good candidate for the implementation of BM due to its property of low loss transmission line which comprises of properties of microstrip and waveguide technology. However, SIW antennas and structures at millimeter waves have unwanted radiation loss coming from the vias holes. In addition, the vias separation distance is dependent on waveguide size, which leads to a more massive beamforming network at 26-GHz. Hence, this thesis is proposing a more size-friendly and optimal SIW antenna beamforming structure to reduce the vias loss and provides higher bandwidth and gain at 26 GHz. The BM components such as 3 dB coupler, 0 dB crossover, and 45-degree phase shifter are designed by implementing metallic vias determination method. Size and distance of vias are the most important factors in determining the coupling ratio and phase shifts at output ports. Hence, the coupler is designed with different vias width and distance to obtain the correct phase and coupling at output ports. Then, the designed coupler is cascaded to form a 0-dB crossover. The phase shifter is designed with alerting vias distance inside the coupling area of SIW structure. The last component in beamforming is the design of SIW slot antenna based on longitude slot distributions. All the components are integrated to form a $4\times4$ BM with four slot antennas attached to BM networks. Microtrip separation feedline used to for coupler, crossover, BM and BFN. The proposed designs are simulated using CST software and fabricated by PCB LPKF ProtoMat printer. The outcomes of wide bandwidth with more than 1-GHz and high directive gain of more than 10-dB for the beamforming network are achieved. The output power of the BM is between −6-dB to −8-dB at all four ports with phase difference error less than 5°. Four directive beams are achieved at beam scanning of −14°, −41°, 40°, and −14° at port 1 to port 4 respectively. Hence, this $4\times4$ -BM with four slot antenna theses have introduced a successful design of an antenna beamforming network based on SIW technology with significant characteristics at 26-GHz.

In this study, an altered differential evolution (ADE) is presented for numerical and engineering problem optimization. It incorporates innovative mutation strategy with new control parameters using the perception of particle swarm optimization (PSO) process, to enhance exploration and exploitation activities extra profusely and increase the global search capacity. Also, a new crossover rate is employed in ADE, to attain higher convergence accuracy and quality optimal solutions. Finally, a novel selection strategy is introduced in ADE, to facilitate information sharing as well as for escaping local minima and keeps progressing. To investigate the suggested ADE performance, a collection of 13 classical benchmark functions, CEC2014 and CEC2017 benchmark suite are solved. Furthermore, the superiority and applicability of the ADE algorithm are further demonstrated through experimentation on six famous real-life engineering problems. The experimental and statistical test outcomes, collectively indicate that compared to other modern optimization algorithms, overall ADE exhibits superior performance. Also, comparison results show that ADE has powerful exploration and exploitation capabilities, excellent convergence performance, and strong ability for gaining high quality solution.

The exploration of premium and new locations is regarded as a fundamental function of every evolutionary algorithm. This is achieved using the crossover and mutation stages of the differential evolution (DE) method. A best-and-worst position-guided novel exploration approach for the DE algorithm is provided in this study. The proposed version, known as "Improved DE with Best and Worst positions (IDEBW)", offers a more advantageous alternative for exploring new locations, either proceeding directly towards the best location or evacuating the worst location. The performance of the proposed IDEBW is investigated and compared with other DE variants and meta-heuristics algorithms based on 42 benchmark functions, including 13 classical and 29 non-traditional IEEE CEC-2017 test functions and 3 real-life applications of the IEEE CEC-2011 test suite. The results prove that the proposed approach successfully completes its task and makes the DE algorithm more efficient. [ABSTRACT FROM AUTHOR]

Introduction: About 50% of patients who sustain an anterior cruciate ligament (ACL) injury are treated without ACL reconstruction (ACL‐R). A significant proportion of these patients opt for late ACL‐R. Patients' experience of changing treatment has not yet been investigated and presented in the scientific literature. Aim: To explore patients' experiences before and after changing treatment from ACL rehabilitation alone to ACL‐R. Method: Fifteen patients were interviewed in semi‐structured interviews, which were recorded, transcribed, and analyzed with qualitative content analysis, based on the method described by Graneheim and Lundman. Patients were between 26 and 58 years old, and had tried rehabilitation for a minimum of 9 months prior to ACL‐R. Results: Two themes, "Expecting what could not be achieved: the struggle to recover and not becoming stable", and "Internal completeness: expectations can be achieved", emerged from the analysis. Each theme was supported by three main categories and 5–6 subcategories. The first theme represents the journey before ACL‐R, where patients experienced getting stronger, but perceived the knee as unstable. The second theme represents the journey after ACL‐R, where patients expressed that they felt whole after their ACL‐R, and where able to achieve their expections. Patients experienced a greater support from the healthcare system, and ultimately expressed a feeling of having achieved the unachievable after ACL‐R. Summary: Patients who cross over from ACL rehabilitation to ACL‐R experienced rehabilitation alone as insufficient to achieve the desired outcomes, which resulted in a need to opt for delayed ACL‐R. Healthcare providers need to support patients, who primarily choose to undergo rehabilitation alone and later opt for ACL‐R, throughout the whole rehabilitation process. [ABSTRACT FROM AUTHOR]

Both an acute bout, as well as chronic static stretching (SS), can increase the joint range of motion (ROM). However, ROM increases of a non‐stretched muscle (non‐local) are reported following an acute SS session, and these effects have not been studied for long‐term SS training. Therefore, this study aimed to investigate the effects of a comprehensive 7‐week SS training program of the pectoralis muscles on ankle dorsiflexion ROM. Thirty‐three healthy, physically active participants (20 male and 13 female) were assigned to either the SS (n = 18) or the control (n = 15) group. The SS group performed a 7‐week SS intervention that comprised three sessions a week, including three exercises of the pectoralis muscles for 5‐min each. Before and after the intervention period, the ankle dorsiflexion ROM was tested with a dynamometer. There was no significant time (p = 0.93, F1,31 = 0.008; η2 = 0.000) or time x group effect (p = 0. 56, F1,31 = 0.342; η2 = 0.011) in ankle dorsiflexion ROM, indicating no changes in ROM in the intervention as well as the control group. Although previous studies on the acute effects of stretching reported non‐local increases in ROM, our study showed no such changes after 7 weeks of SS training. Consequently, if the goal is to chronically increase the ROM of a specific joint, it is recommended to directly stretch the muscles of interest. Highlights: This is the first study that investigated the chronic non‐local effects of stretching.The results showed no significant changes in the range of motion in the non‐stretched tissues.If the goal is to chronically increase the ROM of a specific joint by stretching, it is recommended to directly stretch the muscles of interest. [ABSTRACT FROM AUTHOR]

Most evolutionary algorithms have multiple parameters and their values drastically affect the performance. Due to the often complicated interplay of the parameters, setting these values right for a particular problem (parameter tuning) is a challenging task. This task becomes even more complicated when the optimal parameter values change significantly during the run of the algorithm since then a dynamic parameter choice (parameter control) is necessary. In this work, we propose a lazy but effective solution, namely choosing all parameter values (where this makes sense) in each iteration randomly from a suitably scaled power-law distribution. To demonstrate the effectiveness of this approach, we perform runtime analyses of the (1 + (λ , λ)) genetic algorithm with all three parameters chosen in this manner. We show that this algorithm on the one hand can imitate simple hill-climbers like the (1 + 1) EA, giving the same asymptotic runtime on problems like OneMax, LeadingOnes, or Minimum Spanning Tree. On the other hand, this algorithm is also very efficient on jump functions, where the best static parameters are very different from those necessary to optimize simple problems. We prove a performance guarantee that is comparable to the best performance known for static parameters. For the most interesting case that the jump size k is constant, we prove that our performance is asymptotically better than what can be obtained with any static parameter choice. We complement our theoretical results with a rigorous empirical study confirming what the asymptotic runtime results suggest. [ABSTRACT FROM AUTHOR]

Background: Prehospital care for cold-stressed and hypothermic patients focuses on effective insulation and rewarming. When encountering patients wearing wet clothing, rescuers can either remove the wet clothing before isolating the patient or isolate the patient using a vapor barrier. Wet clothing removal increases skin exposure but avoids the need to heat the wet clothing during rewarming. Leaving wet clothing on will avoid skin exposure but is likely to increase heat loss during rewarming. This study aimed to evaluate the effect of wet clothing removal compared to containing the moisture using a vapor barrier on skin temperature in a prehospital setting. Methods: This randomized crossover experimental field study was conducted in a snow cave in Hemsedal, Norway. After an initial cooling phase of 30 min while wearing wet clothes, the participants were subjected to one of two rewarming scenarios: (1) wet clothing removal and wrapping in a vapor barrier, insulating blankets, and windproof outer shell (dry group) or (2) wrapping in a vapor barrier, insulating blankets, and windproof outer shell (wet group). The mean skin temperature was the primary outcome whereas subjective scores for both thermal comfort and degree of shivering were secondary outcomes. Primary outcome data were analyzed using the analysis of covariance (ANCOVA). Results: After an initial decrease in temperature during the exposure phase, the dry group had a higher mean skin temperature compared to the wet group after only 2 min. The skin-rewarming rate was highest in the initial rewarming stages for both groups, but increased in the dry group as compared to the wet group in the first 10 min. Return to baseline temperature occurred significantly faster in the dry group (mean 12.5 min [dry] vs. 28.1 min [wet]). No intergroup differences in the subjective thermal comfort or shivering were observed. Conclusion: Removal of wet clothing in combination with a vapor barrier increases skin rewarming rate compared to encasing the wet clothing in a vapor barrier, in mild cold and environments without wind. Trial registration: ClinicalTrials.gov ID NCT05996757, retrospectively registered 18/08/2023. [ABSTRACT FROM AUTHOR]

Summary: This paper proposes a high‐selective crossover with a third‐order filtering characteristic, high passband isolation, and multiple controllable transmission zeros based on a coupled topology using single‐ and dual‐mode resonators. By virtue of the odd‐ and even‐mode feature of the stub‐loaded dual‐mode ring resonator, not only can the two resonant modes for different passbands be relatively independently controlled, but also better isolation can be achieved. With a single‐mode resonator and stub‐loaded dual‐mode resonant coupling topology, the resultant crossover can perform third‐order filtering performance in two distinct passbands/channels and generate several transmission zeros outside the desired bands to improve the isolation between the passbands. Experimental results demonstrate that, compared with conventional works, the filtering order of the proposed crossover is promoted and its passband isolation can be significantly improved by about 8 dB. The proposed work may facilitate its widespread applications in high‐performance multichannel integrated microwave systems for avoiding interference between multiple intersecting signal paths. [ABSTRACT FROM AUTHOR]

The identification and repair of structural damage in building foundations are critical tasks in ensuring the safety and integrity of civil infrastructure. This research paper proposes a method based on genetic algorithms for the identification and repair of structural damage in building foundations. The proposed approach begins with the identification of structural damage by analysing sensor data, including vibration measurements and strain gauges, obtained from the building's foundation. A genetic algorithm is then employed to optimize the identification process by iteratively searching for the most likely damage scenarios based on the collected sensor data. Once the damage is identified, the algorithm proceeds to develop an optimal repair strategy. It considers various parameters, such as available repair materials, budget constraints, and desired structural performance, to generate a repair plan that minimizes cost and maximizes the restoration of structural integrity. The repair plan is optimized using the genetic algorithm to find the best combination of repair techniques and materials. To evaluate the effectiveness of the proposed method, extensive simulations and case studies are conducted on different types of building foundations. The performance of the algorithm is assessed in terms of its accuracy in identifying structural damage and the efficiency of the repair strategy. [ABSTRACT FROM AUTHOR]

In the field of post-quantum security, isogeny-based cryptography stands out for its ability to fight quantum attacks. One of the key operations in isogeny-based schemes is finite field multiplication, which plays a crucial role in cryptographic protocols such as key exchange and digital signatures. To ensure practical implementations of these schemes, efficient finite field multiplication is essential. In this research, a novel optimization approach, the Crossover-Boosted Water Cycle Algorithm (CB-WCA), to enhance the efficiency of finite field multiplication in isogeny-based cryptography is proposed. By using both the WCA and a crossover method inspired by genetic algorithms, the CB-WCA effectively explores solution areas, aiming for the best solutions. The formulation of the finite field multiplication optimization problem and an objective function that quantifies the efficiency of the multiplication process based on computational cost is presented and defined. The CB-WCA is then applied to find the optimal set of parameters for finite field multiplication algorithms. Extensive experimental evaluations are conducted, comparing the performance of the CB-WCA-optimized algorithms with traditional optimization methods and other metaheuristic algorithms. Through the findings, it is evident that the CB-WCA stands out for its ability to achieve faster execution times and decrease computational costs. Furthermore, the optimized finite field multiplication algorithms are integrated into isogeny-based cryptographic schemes and evaluate their impact on cryptographic protocol efficiency and security. Real-world implementations showcase the practical applicability of the optimized algorithms in hardware and software environments. To ensure the security of the optimized algorithms, rigorous cryptanalysis is performed to verify their resilience against potential attacks, ensuring they meet the highest standards of security. [ABSTRACT FROM AUTHOR]

Summary: Mutations affecting crossover (CO) frequency and distribution lead to the presence of univalents during meiosis, giving rise to aneuploid gametes and sterility. These mutations may have a different effect after chromosome doubling. The combination of altered ploidy and mutations could be potentially useful to gain new insights into the mechanisms and regulation of meiotic recombination; however, studies using autopolyploid meiotic mutants are scarce.Here, we have analyzed the cytogenetic consequences in colchicine‐induced autotetraploids (colchiploids) from different Arabidopsis mutants with an altered CO frequency.We have found that there are three types of mutants: mutants in which chiasma frequency is doubled after chromosome duplication (zip4, mus81), as in the control; mutants in which polyploidy leads to a higher‐than‐expected increase in chiasma frequency (asy1, mer3, hei10, and mlh3); and mutants in which the rise in chiasma frequency produced by the presence of two extrachromosomal sets is less than doubled (msh5, fancm). In addition, the proportion of class I/class II COs varies after chromosome duplication in the control.The results obtained reveal the potential of colchiploid meiotic mutants for better understanding of the function of key proteins during plant meiosis. This is especially relevant considering that most crops are polyploids. [ABSTRACT FROM AUTHOR]

Reciprocal exchanges of DNA between homologous chromosomes during meiosis, or crossovers (COs), shuffle genetic information in gametes and progeny. In many eukaryotes, the majority of COs (class I COs) are sensitive to a phenomenon called interference, which influences the occurrence of closely spaced double COs. Class I COs depend on a group of factors called ZMM (Zip, Msh, Mer) proteins including HEI10 (Human Enhancer of Invasion-10). However, how these proteins are recruited to class I CO sites is unclear. Here, we show that HEI10 forms foci on chromatin via a liquid-liquid phase separation (LLPS) mechanism that relies on residue Ser70. A HEI10S70F allele results in LLPS failure and a defect in class I CO formation. We further used immunoprecipitation-mass spectrometry to identify RPA1a (Replication Protein A 1) as a HEI10 interacting protein. Surprisingly, we find that RPA1a also undergoes phase separation and its ubiquitination and degradation are directly regulated by HEI10. We also show that HEI10 is required for the condensation of other class I CO factors. Thus, our results provide mechanistic insight into how meiotic class I CO formation is controlled by HEI10 coupling LLPS and ubiquitination. [ABSTRACT FROM AUTHOR]

Successful chromosome segregation into gametes depends on tightly regulated interactions between the parental chromosomes. During meiosis, chromosomes are aligned end-to-end by an interface called the synaptonemal complex, which also regulates exchanges between them. However, despite the functional and ultrastructural conservation of this essential interface, how protein-protein interactions within the synaptonemal complex regulate chromosomal interactions remains poorly understood. Here, we describe a genetic interaction in the C. elegans synaptonemal complex, comprised of short segments of three proteins, SYP-1, SYP-3, and SYP-4. We identified the interaction through a saturated suppressor screen of a mutant that destabilizes the synaptonemal complex. The specificity and tight distribution of suppressors suggest a charge-based interface that promotes interactions between synaptonemal complex subunits and, in turn, allows intimate interactions between chromosomes. Our work highlights the power of genetic studies to illuminate the mechanisms that underlie meiotic chromosome interactions. [ABSTRACT FROM AUTHOR]

The restricted Boltzmann machine (RBM) is a generative neural network that can learn in an unsupervised way. This machine has been proven to help understand complex systems, using its ability to generate samples of the system with the same observed distribution. In this work, an Ising system is simulated, creating configurations via Monte Carlo sampling and then using them to train RBMs at different temperatures. Then, 1. the ability of the machine to reconstruct system configurations and 2. its ability to be used as a detector of configurations at specific temperatures are evaluated. The results indicate that the RBM reconstructs configurations following a distribution similar to the original one, but only when the system is in a disordered phase. In an ordered phase, the RBM faces levels of irreproducibility of the configurations in the presence of bimodality, even when the physical observables agree with the theoretical ones. On the other hand, independent of the phase of the system, the information embodied in the neural network weights is sufficient to discriminate whether the configurations come from a given temperature well. The learned representations of the RBM can discriminate system configurations at different temperatures, promising interesting applications in real systems that could help recognize crossover phenomena. [ABSTRACT FROM AUTHOR]

In Slovenian (youth) literature, three authors who have worked in the field of drama and/or theatre stand out – namely, Svetlana Makarovič, academically trained actress (Sapramiška), Milan Jesih (Four Plays for Children, adaptations of Andersen’s fairy tales The Emperor’s New Clothes and The Ugly Duckling) and Andrej Rozman Roza. The paper will focus on the latter, who was strongly influenced by the theatre experiment in Slovenia, especially during the formative period of his studies of the Slovenian language (1974–1978). Andrej Rozman Roza (1956) started performing and/or publishing plays in the period 1981–1990 (Inspector Schwake, 1986; collection of texts Ana Monró Theatre, 1991, etc.). He is known in literary history as a youth poet and is included in Slovenian language curricula (1998, 2011, 2018). However, the definition of a systemic author is more appropriate for him (I. Even Zohar, M. Dović) since of the six functions in the literary system (author, institution, market, repertoire, book, reader) he holds at least three roles (author, “institution”, book [living book], etc.). This paper focuses on adaptations of classics of Slovenian (Cankar, Levstik, Linhart, Prešeren, etc.) or world literature that – regardless of literary genre or type – have become crossover literature in the process of literary reception, especially in picture-book editions (e.g., A Midsummer Night’s Dream which has the international fairy tale type number ATU 899A [Pyramus and Thisbe]). According to B. Kümmerling-Meibauer’s definition of crossover classics or authorship, Rozman is a crossover author. In addition, according to L. Hutcheon’s theory, adaptations are an important part of Rozman’s work and contribute to the updating of classics and modern classics. The paper presents the collection Brvi čez morje (The Footbridge Across the Sea), which contains thirteen plays, three of which are folktale texts – Janko and Metka (Hansel and Gretel) [ATU 327], Obuti maček ( Puss in Boots) [ATU 545B], Vžigalnik (The Tinderbox) [ATU 562] – and one which is a fairy tale, Kekec [ATU 1137]). Intertextually, they refer to folktale types.

Electrification of the chemical industry has been considered an enabler for energy transition on a massive scale. In this context, carbon monoxide electroreduction (COR) to produce multi‐carbon (C2+) products is considered one of the forefront emerging technologies. The key challenge in COR comes from the excessive cation crossover to the cathode via electromigration and water diffusion, which limits CO availability and impedes product selectivity. Commercial anion exchange membrane (AEM) suppresses the electromigration of cations, however, suffers from water diffusion which facilitates cation crossover. Here, we tackled these problems emerging from cation crossover and water diffusion by directly depositing an ultrathin Nafion ionomer on the cathode (sputtered Cu) surface. Our approach enables full‐cell energy efficiency of 21 % for converting CO into ethylene (C2H4) at 100 mA/cm2 with over 200 hours of stable operation. We also exhibited record high energy efficiency for ethanol (C2H5OH) production with CO‐to‐C2H5OH electrolysis efficiency of 17 %. This approach to directly depositing ultrathin ionomer on the cathode to enhance system performance may benefit other electrochemical systems to overcome challenges associated with scalability, stability, and efficiency to produce high‐value chemicals. [ABSTRACT FROM AUTHOR]

Introduction: Meiotic recombination (or crossover, CO) is essential for gamete fertility as well as for alleles and genes reshuffling that is at the heart of plant breeding. However, CO remains a limited event, which strongly hampers the rapid production of original and improved cultivars. RecQ4 is a gene encoding a helicase protein that, when mutated, contributes to improve recombination rate in all species where it has been evaluated so far. Methods: In this study, we developed wheat (Triticum aestivum L.) triple mutant (TM) for the three homoeologous copies of TaRecQ4 as well as mutants for two copies and heterozygous for the last one (Htz-A, Htz-B, Htz-D). Results: Phenotypic observation revealed a significant reduction of fertility and pollen viability in TM and Htz-B plants compared to wild type plants suggesting major defects during meiosis. Cytogenetic analyses of these plants showed that complete absence of TaRecQ4 as observed in TM plants, leads to chromosome fragmentation during the pachytene stage, resulting in problems in the segregation of chromosomes during meiosis. Htz-A and Htz-D mutants had an almost normal meiotic progression indicating that both TaRecQ4-A and TaRecQ4-D copies are functional and that there is no dosage effect for TaRecQ4 in bread wheat. On the contrary, the TaRecQ4-B copy seems knocked-out, probably because of a SNP leading to a Threonine>Alanine change at position 539 (T539A) of the protein, that occurs in the crucial helicase ATP bind/DEAD/ResIII domain which unwinds nucleic acids. Occurrence of numerous multivalents in TM plants suggests that TaRecQ4 could also play a role in the control of homoeologous recombination. Discussion: These findings provide a foundation for further molecular investigations into wheat meiosis regulation to fully understand the underlying mechanisms of how TaRecQ4 affects chiasma formation, as well as to identify ways to mitigate these defects and enhance both homologous and homoeologous recombination efficiency in wheat. [ABSTRACT FROM AUTHOR]

There has been a massive development of metaheuristic algorithms in the latest decade where swarm intelligence becomes the fundamental approach. Meanwhile, there is still no ideal metaheuristic that can solve all problems superiorly, as declared in the no-free-lunch (NFL) theory. This work introduces a novel swarm-based metaheuristic named as migration-crossover algorithm (MCA). In MCA, the swarm intelligence is enriched with the crossover technique and the neighbourhood search with unbalanced local search space. The global finest solution becomes the reference in the first step while the middle between two stochastically chosen solutions becomes the reference in the second step. The neighbourhood search is performed in the third step. The collection of 23 functions become the use case during the evaluation of MCA. In the first evaluation, MCA is compared with five new metaheuristics: total interaction algorithm (TIA), osprey optimization algorithm (OOA), migration algorithm (MA), coati optimization algorithm (COA), and walrus optimization algorithm (WaOA). The result reveals that MCA is finer than TIA, OOA, MA, COA, and WaOA in 20, 19, 17, 20, and 17 functions subsequently. The result of the second evaluation reveals that the global finest solution becomes the dominant contributor in the high dimension functions while the middle between two stochastically chosen solutions becomes the dominant contributor in the fixed dimension functions. [ABSTRACT FROM AUTHOR]

Meiosis is a distinctive type of cell division that reorganizes genetic material between generations. The initial stages of meiosis consist of several crucial steps which include double strand break, homologous chromosome pairing, break repair and crossover. Crossover frequency varies depending on the position on the chromosome, higher at euchromatin region and rare at heterochromatin, centromeres, telomeres and ribosomal DNA. Crossover positioning is dependent on various factors, especially epigenetic modifications. DNA methylation, histone post-translational modifications, histone variants and non-coding RNAs are most probably playing an important role in positioning of crossovers on a chromosomal level as well as hotspot level. DNA methylation negatively regulates crossover frequency and its effect is visible in centromeres, pericentromeres and heterochromatin regions. Pericentromeric chromatin and heterochromatin mark studies have been a centre of attraction in meiosis. Crossover hotspots are associated with euchromatin regions having specific chromatin modifications such as H3K4me3, H2A.Z. and H3 acetylation. This review will provide the current understanding of the epigenetic role in plants during meiotic recombination, chromosome synapsis, double strand break and hotspots with special attention to euchromatin and heterochromatin marks. Further, the role of epigenetic modifications in regulating meiosis and crossover in other organisms is also discussed. [ABSTRACT FROM AUTHOR]

In the present paper, the genetic algorithm and some of its variants i.e. adaptive genetic algorithm, binary-coded genetic algorithm and real-coded genetic algorithm are applied to the Asymmetric Traveling Salesman Problem (ATSP). ATSP is one of the most widely studied combinatorial NP-hard problems of finding the shortest path. The present ATSP is a novel real-life case of the shortest path problem based on the distances between 22 districts of Haryana, India. To solve the above problem, one-point crossover and exchange mutation are applied to compare the performance of these algorithms on different parameters such as the size of the population, the number of iterations, and the rate of crossover. The main objective of this paper is to study the influence of these parameters on ATSP. Numerical results show that the binary genetic algorithm worked better in terms of the size of the population and the number of iterations, while the real-coded genetic algorithm worked better in terms of the rate of crossover. [ABSTRACT FROM AUTHOR]

This article aims to provide a concise overview of the most relevant topics concerning the implementation of acceptability judgments in generative research. The first part focuses on theoretical issues, including the reasons underlying the prevalence of acceptability judgments, the skepticism towards the wide use of informal judgments, the arguments for and against the continued use of informal data points and the challenges related to experimental data collection and the gradient nature of judgments. The second part further explores the concept of gradient acceptability and its different sources. We suggest that violations of soft constraints correspond with partial acceptability, unlike violations of hard constraints, which cause strong unacceptability. Based on our investigation of selected partially acceptable syntactic phenomena in Polish, we show that their syntactic accounts can also benefit from the inclusion of non-syntactic factors, which can be more reliably identified via experimental methodology. More specifically, we propose that (i) the lack of subject orientation of pronominal possessives could be attributed to lexical ambiguity, (ii) coreference of possessive cataphora is facilitated by antecedent backgrounding and (iii) WCO is improved by focus marking of the possessive pronoun, (iv) while processing of the last two structures could be ameliorated with more informative fillers. [ABSTRACT FROM AUTHOR]

Abstract Background Recombination reshuffles alleles at linked loci, allowing genes to evolve independently and consequently enhancing the efficiency of selection. This makes quantifying recombination along chromosomes an important goal for understanding how selection and drift are acting on genes and chromosomes. Results We present RecView, an interactive R application and its homonymous R package, to facilitate locating recombination positions along chromosomes or scaffolds using whole-genome genotype data of a three-generation pedigree. RecView analyses and plots the grandparent-of-origin of all informative alleles along each chromosome of the offspring in the pedigree, and infers recombination positions with either of two built-in algorithms: one based on change in the proportion of the alleles with specific grandparent-of-origin, and one on the degree of continuity of alleles with the same grandparent-of-origin. RecView handles multiple offspring and chromosomes simultaneously, and all putative recombination positions are reported in base pairs together with an estimated precision based on the local density of informative alleles. We demonstrate RecView using genotype data of a passerine bird with an available reference genome, the great reed warbler (Acrocephalus arundinaceus), and show that recombination events can be located to specific positions. Conclusions RecView is an easy-to-use and highly effective application for locating recombination positions with high precision. RecView is available on GitHub ( https://github.com/HKyleZhang/RecView.git ).

One of the major concerns for service providers and application developer are Quality of experience (QoE), where high traffic congestion on the Internet leads to the degradation of video quality. However, the effectiveness of video transmission is minimized due to the network based on packet loss, bandwidth, and delay. Because of bandwidth limitations, the videos transmitted are obtained in low quality. Meanwhile, various outcomes such as reduction in throughput, re-buffering, or mosaic are determined in packet loss which validated the video streaming obtained in reliable or unreliable mode. Therefore this paper proposes an Improved Fuzzy Weighted queueing based Crossover Fire Hawk (IFW-CFH) algorithm for effective real-time video transmission. The objective of the IFW-CFH approach is to reduce the delay, packet loss, and bandwidth to enhance the video quality via two key mechanisms namely congestion control mechanism as well as packet scheduling mechanism. During the generation of encoded video frames, the packaged packets to the local buffer are transmitted by the scheduler using our proposed IFW-CFH algorithm. Finally, the experimentation is conducted and the results show that the proposed method minimized transmission delay, packet loss, and bandwidth by 13.8% for effective real-time video transmission compared to the existing methods. [JJCIT 2023; 9(3.000): 207-219]

Vanadium acetylacetonate (V(acac)3) disproportionation electrochemistry promises a crossover-tolerant, high-voltage flow battery, but exhibits low efficiency and short cycle life. We show that membrane fouling, rather than a parasitic side reaction, dominates early performance fade. Crossover rates through porous membranes were estimated from voltage transients with an adaptive observer while cycling flow-through reactors. For 0.1M V(acac)3 and 0.3M TEABF4 in acetonitrile flowed countercurrently at 5.0cms−1 parallel to the separator, fresh Daramic 175 and Celgard 4650 afforded active-species mass-transfer coefficients of 3.8μms−1 and 7.5μms−1, respectively, which decreased and became non-Fickian as cycling progressed. At ±10mAcm−2 from 0%–20% state of charge, voltage efficiency with Celgard fell from 96% to 60% over 27 cycles. Separator replacement restored the coulombic and voltage efficiencies, which repeated their first progression. Impedance spectra from series-connected canary cells reveal that separator resistances remain stable during open-circuit exposure to charged single electrolytes, but increase under applied current or open-circuit contact with differently charged electrolytes.

IntroductionMeiotic recombination (or crossover, CO) is essential for gamete fertility as well as for alleles and genes reshuffling that is at the heart of plant breeding. However, CO remains a limited event, which strongly hampers the rapid production of original and improved cultivars. RecQ4 is a gene encoding a helicase protein that, when mutated, contributes to improve recombination rate in all species where it has been evaluated so far. MethodsIn this study, we developed wheat (Triticum aestivum L.) triple mutant (TM) for the three homoeologous copies of TaRecQ4 as well as mutants for two copies and heterozygous for the last one (Htz-A, Htz-B, Htz-D).ResultsPhenotypic observation revealed a significant reduction of fertility and pollen viability in TM and Htz-B plants compared to wild type plants suggesting major defects during meiosis. Cytogenetic analyses of these plants showed that complete absence of TaRecQ4 as observed in TM plants, leads to chromosome fragmentation during the pachytene stage, resulting in problems in the segregation of chromosomes during meiosis. Htz-A and Htz-D mutants had an almost normal meiotic progression indicating that both TaRecQ4-A and TaRecQ4-D copies are functional and that there is no dosage effect for TaRecQ4 in bread wheat. On the contrary, the TaRecQ4-B copy seems knocked-out, probably because of a SNP leading to a Threonine>Alanine change at position 539 (T539A) of the protein, that occurs in the crucial helicase ATP bind/DEAD/ResIII domain which unwinds nucleic acids. Occurrence of numerous multivalents in TM plants suggests that TaRecQ4 could also play a role in the control of homoeologous recombination. DiscussionThese findings provide a foundation for further molecular investigations into wheat meiosis regulation to fully understand the underlying mechanisms of how TaRecQ4 affects chiasma formation, as well as to identify ways to mitigate these defects and enhance both homologous and homoeologous recombination efficiency in wheat.

Static stretching and foam rolling can increase the range of motion (ROM) of a joint acutely as well as chronically. Although studies have reported ROM increases of a non-stretched heterologous muscle (non-local) following an acute static stretching or foam rolling session, these effects have not been studied for long-term training interventions. Therefore, the purpose of this study was to investigate the effects of a comprehensive 7-week static stretching and foam rolling training program of the foot sole on shoulder extension ROM. A total of 33 healthy, physically active participants (20 male) were assigned to either the intervention (n = 19) or control (n = 14) group. The intervention group performed a 7-week combined static stretching and foam rolling intervention comprising three sessions a week, including three exercises of the foot sole for 5 min each. Before and after the intervention period, the shoulder extension ROM was tested with three-dimensional (3D) motion caption. The level of significance for all statistical analyses was set to ρ ≤ 0.05. There was no significant time (p = 0.70, F1, 31 = 0.157; η2 = 0.005) or time×group effect (p = 0.38, F1, 31 = 0.785; η2 = 0.025) in shoulder extension ROM, indicating no ROM changes in the intervention or the control group. Although previous studies on the acute effects of stretching and foam rolling reported non-local increases in ROM in heterologous muscles, this study could show that such effects do not occur after chronic SS and foam rolling training for 7 weeks. Consequently, if the goal is to chronically increase the ROM of a specific joint, it is recommended to directly treat the muscles of interest.